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The activated FcRs elicited signaling via the ITAM domain of the FcR chain

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Ferroptosis: Molecular mechanisms and health implications

It is acylated at the N-terminus with a C20 fatty diacid linked via a -glutamic acid spacer, and carries an intramolecular disulfide bond between Cys3 and Cys8 structural modifications that extend its half-life and reduce fibril formation relative to native amylin