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Notably, a study involving approximately 276,000 participants from the UK Biobank cohort revealed that permanent night shift work, a condition acknowledged to reduce 24-hour melatonin levels [41], was associated with a 1.5-fold higher risk of developing AD during a median follow-up of 9 years [42]

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doi: 10.1093/jmcb/mjac042 22 SongWAnselmoACHuangL