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Risk of bias assessment The results of evaluating the quality of the included studies are presented in online Supplementary Fig

Further, the biosynthesis of Sec on tRNA [ser]Sec starts with the loading of a serine residue on tRNA [ser]Sec followed by its phosphorylation through the enzyme O-phosphoseryl-tRNA [Ser]Sec kinase (PSTK) to form phosphoseryl-tRNA [Ser]Sec