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SlyA, a transcriptional regulator of salmonella typhimurium , is required for resistance to oxidative stress and is expressed in the intracellular environment of macrophages

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The relevant basic pharmacological data are shown in Table 2

Consequently, glucose is converted to sorbitol via aldose reductase, which is further converted to fructose by sorbitol dehydrogenase (SDH)

In intact HepG2 cells, the pan-flavoenzyme inhibitor, DPI, prevented the NFT-stimulated increase in glutathione levels, indicating the involvement of one or more of these enzymes in NFT-dependent activation of Nrf2 (Fig