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These include a Creapure (Alzchem) creatine monohydrate combined with AstraGin (NuLiv Science) to support muscle recovery and reduce fatigue, BioCore Optimum Complete Digestive Enzymes Blend (ADM/Deerland Probiotics & Enzymes) to aid in digestion and nutrient absorption, and a vitamin C and glutathione combination formula featuring PureWay-C (One Innovation Labs) and Setria (Kyowa Hakko) for immune support, detoxification and cellular defense

DNA methyltransferase (DNMTs) catalyzes the transfer of a methyl group to these sites from a donor molecule, like S-adenosyl-L-methionine (SAM) 5,6

Acknowledgements We would like to acknowledge the Excellence of Diabetes Research in Sweden (www.exodiab.se)in biobank for providing the samples, and the Swedish Metabolomics Centre (www.swedishmetabolomicscentre.se) for the MS and the computational identification of the compounds

doi: 10.1136/bmj.f1169

However, like all medical procedures, there is a small risk of side effects