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For someone with documented deficiency, on long-term metformin or a PPI, or with confirmed absorption problems, step up to a higher-potency option like Jarrow Methyl B-12 5,000 mcg under a clinician's guidance

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2023 Apr;141:109104

The trial measured changes in body weight, waist circumference, fat mass (via DEXA), and metabolic parameters including glucose and lipid profiles

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