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Intervention with heat-sterilized Bifidobacterium breve M-16V could reduce the abundance levels of bacteria to prevent CSDS-induced depression and IL-1 expression (Kosuge et al., 2021)

By the adapter protein DDB1, the core is connected to various exchangeable substrate receptors called DCAFs, forming various cellular CRL4 E3s with different specificities (Zimmerman et al , 2010)