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Activated T cells express integrins and chemokine receptors that allow them to adhere to and penetrate the brain endothelial lining, which is often upregulated with adhesion molecules during MS flares

MTHFR itself is a folate-cycle enzyme, not a B12 enzyme it generates 5-methyltetrahydrofolate, the methyl donor that methionine synthase uses together with methylcobalamin to remethylate homocysteine

Breast CSCs exhibit unlimited proliferation and diverse differentiation potential, and consequently promote tumor immune evasion

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doi: 10.1080/07315724.2005.10719490