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Therefore, therapeutic strategies that manipulate ROS levels, either by increasing oxidative stress to promote cell death or by targeting antioxidant pathways to inhibit tumor growth, are being explored 118

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Ultimately, these factors create a vicious cycle that contributes to HF

113 RajicA.WaddellL

Furthermore, to robustly quantify the transcriptomic similarity between tumor cells and myeloid cells, we calculated at single cell resolution multiple metrics, including Manhattan and Euclidean distance metrics, the Cosine and Pearson correlation-based directional similarity metrics, as well as the Phi and Bray-Curtis proportionality and compositional dissimilarity metrics 22,23