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DECLARATIONS Authors contributions Drafted the manuscript: Valds-Calero I Revised the manuscript critically for important intellectual content: Rodrguez A, Frhbeck G All authors participated in final approval of the version to be published

Although we advocate for the use of newer technology such as CCM and Sudoscan, there remains substantial value in simple routine clinical testing in resource-limited settings

In most clinical protocols, HCG is administered two to three times per week in low, divided doses (typically 250500 IU per injection)

Iron deficiency is directly linked to poor cognitive function

Trial Design Considerations REDEFINE-1 Used Flexible Dosing: Investigators could reduce dose if patients experienced intolerable side effects