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Animal experiments were approved by the Wako Animal Experiment Committee in RIKEN (approval number: W2021-2-020(1))

So why not switch to tirzepatide for a while, then switch back

Subsequently, NLRP3 leads to the activation of caspase 1

During sepsis, immune cells such as neutrophils and macrophages are rapidly activated in response to microbial invasion, releasing large amounts of ROS, including superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH ), as part of the hosts antimicrobial arsenal (Di Meo et al., 2016)