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The HMGB1/5HT7R/Nrf2/xCT/GPX4 pathway was found to promote ferroptosis of M2 microglia in transient middle cerebral artery occlusion (tMCAO) mice, which promoted ischemic brain injury and depressive-like behaviors

Given that microglia can exhibit both pro-inflammatory and anti-inflammatory phenotypes depending on the context, future research is likely to explore ways to fine-tune microglial responses to promote neuroprotection and reduce neuroinflammation

For research math, identify the vial strength, confirm whether it is a blend or separate compound vial, add the bacteriostatic water volume, and calculate U-100 syringe units from the resulting concentration

doi: 10.1016/j.molcel.2019.02.038 46 HuJTianM

10.3390/ijms14047405 78 ZhangB.ShangS.ZhangH.JabeenZ.ZhangG