10.1038/nature22393 233 WangY.LiC.AliI.LiL.WangG
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Prolonged metabolic stress impairs mitophagy and reduces mitochondrial function, as indicated by decreased oxidative phosphorylation, impaired ATP synthesis, and elevated reactive oxygen species (ROS) generation ( Hepatic lipid overload can also directly initiate inflammatory signaling by activating resident immune cells
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