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Our findings demonstrate that senescence-induced inflammation promotes accumulation of CD38 in immune cells that, through its ecto-enzymatic activity, decreases levels of NMN and NAD +

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Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+

For stronger data integrity, studies should include suitable controls, repeat measurements, documented acceptance criteria, and a clear distinction between exploratory findings and validated conclusions