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Sources of B12 In nature, a range of bacteria manufacture vitamin B12

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a regioselective nitration of 14 may be used to selectively install a nitro group at the C3 position of compound 14 or the like, followed by chlorination of the quinoline-N-oxide moiety in the presence of POCl 3 to give intermediate 15

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Studies suggest 3065% of products may be contaminated or mislabeled, with risks including endotoxins, heavy metals, and incorrect sequences