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Description

Extensive site-directed mutagenesis, ligand binding analysis, determination of pHrate profiles, and solvent deuterium isotope effects established the reaction mechanism for Arabidopsis GS and for the eukaryotic homologs (Herrera et al., 2007)

We have chosen prpTDP-43 A315T mice for our analyses, because this mouse model of TDP-43 pathology was generated based on the A315T mutation detected in the TARDP gene of ALS patients, who had TDP-43 pathology in their cortex 19 , and because the mouse model strictly recapitulated many aspects of the disease, including progressive CSMN degeneration 16