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Bender, D

College of Liberal Arts & Sciences Evelyn Jones, Eudora, Kansas

We find that the cancer-related truncated variants comprising residues 1-645 and 1-591 of ASXL1 (ASXL1 1-645 and ASXL1 1-591 ) retain BRD4 binding function, with ASXL1 1-645 showing an enhanced ability to recruit BRD4 to promoters of ASXL1 target genes