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[] There is controversy about the liver to the skeletal muscle crosstalk in patients with comorbidity of NAFLD and sarcopenia, as that NAFLD and sarcopenia share many complex interplaying mechanisms, including insulin resistance and myostatin and adiponectin homeostasis, which make it difficult to determine the actual cause, therefore, identifying whether sarcopenia is a cause, consequence, both, or neither of fatty liver is challenging

The BCAA transporter SLC7A5 is upregulated in multiple cancers, facilitating increased BCAA influx [218]

13,216,217 The most relevant challenges can be summarized as follows

Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, et al

Lactobacillus cofermentation of cerasus humilis juice alters chemical properties, enhances antioxidant activity, and improves gut microbiota