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doi: 10.3389/fphar.2023.1147414 Received 18 January 2023 Accepted 22 February 2023 Published 02 March 2023 Volume 14 - 2023 Edited by Zhihao Liu, Dalian Medical University, China Reviewed by Ral Gonzalez Ojeda, University of Galway, Ireland Hang Liu, University of California, Los Angeles, United States Updates Copyright 2023 Pei, Pan, Wei and Hua

The fundamental processes underlying control of the cellular redox environment will now be discussed

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IRE1 inhibition with KIRA6 or 48C reduces ER stress, neuronal death, and tau aggregation in PD, ALS, and AD models

As a consequence, TME is reshaped into a highly oxidative and immunosuppressive nichea hostile filter that selectively pressures infiltrating immune populations