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Throughout this proposed rule, and in the context of the word cause or causes used in the textual warning statements included therein, FDA relied on the four-level classification provided in the Surgeon General's Reports

Scores (out of 60) for each of these three categories were combined and summarised in population quintiles ranging from the first quintile lowest socioeconomic status (SES) to the fifth highest SES [24]

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Smaller vaping companies also wanted to get into the market, creating both vape juices and hardware