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With respect to the substantial similarity criteria, the applicant asserted that XENOVIEW TM is not substantially similar to other currently available technologies because HP 129 Xe, a new chemical entity, and new lung MRI signaling agent, is created on-site following an FDA approved method, for oral inhalation

doi:10.1021/acs.jpcb.8b07634

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Sikiric P, Seiwerth S, Rucman R, Kolenc D, Vuletic LB, Drmic D, et al