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Studies have shown that the expression of GLS in some breast cancer and nervous system tumors is higher than that in normal tissues, and the use of small molecule GLS inhibitors such as BPTES, CB-839 and compound 968 can significantly inhibit the growth of tumor cells (100)

Third, the retrospective observational design of our study does not allow us to establish a clear causal connection and presents challenges in identifying the exact cause of GGT variability

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Several commenters noted the limited health IT infrastructure available to report the measure, particularly for smaller and rural hospitals, which presents significant barriers to implementation