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The combination of disulfiram (DSF) and Cu2 + was found to induce ROS production, triggering the proapoptotic-related c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) pathways while inhibiting the anti-apoptotic nuclear factor kappa B (NF- B) pathway, ultimately resulting in apoptosis of breast cancer cells [98]

Further comparative transcriptomic and metabolomic analyses of primary and LN-metastatic tumors in mice with melanoma found that LN metastases require a metabolic shift toward fatty acid oxidation (FAO) (108)

Biomimetic nanoparticles encapsulating rapamycin have been shown to efficiently penetrate the bloodbrain barrier, induce protective autophagy and reduce oxidative stress in autism and glioblastoma models