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These adjustments encompassed maintaining regular sleep patterns, avoiding late nights, abstaining from alcohol and tobacco, and avoiding chronic exposure to heat (including fever), radiation, and toxins

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Further supporting this finding, we detected enrichment of induced G-quadruplex structures in both SWI/SNF, PRC2, and NuRD subunit binding sites in a variety of ENCODE ChIP-sequencing (ChIP-seq) datasets, consistent with our in vitro binding data (Supplementary Fig

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