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Furthermore, partial epigenetic reprogramming falls under the umbrella of experimental therapeutics known as cellular rejuvenation, which several well-funded biotech startups, backed by high-profile executives, have focused on in recent years

Moreover, alteration of the administration order of Bu-Cy to Cy-Bu gives the same engraftment outcome but reduces the toxicity of the conditioning regimen both in patients and mice 59,60

Research protocols sometimes combine matrikine signals with broader gene modulators to address both the targeted collagen induction pathway and the broader tissue remodeling network simultaneously

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