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doi: 10.12659/MSM.908422 135

Bile acids can also play a role in cardiovascular function by reducing heart rate through regulating channel conductance and calcium dynamics in sin-atrial and ventricular cardiomyocytes and regulating vascular tone [70]

NLRP3 inflammasome activation exacerbates oxidative stress and endothelial dysfunction, while inhibition of the NLRP3 inflammasome signaling pathway can ameliorate vascular dysfunction (184)