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In parallel, DTP cells exploit compensatory signaling circuits, including pathways such as AURKB, JNK, PI3K, and FAK-YAP, which remain active when major oncogenic drivers such as EGFR, BRAF, or MEK are inhibited ( DTP states can arise under different therapeutic exposure paradigms, including acute high-dose treatment and chronic, continuous drug exposure

Lipid replacement therapy: a functional approach to mitochondrial dysfunction

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Int J Mol Sci 23(9):4612

An 18-mo randomized, double-blind, placebo-controlled trial of DHA-rich fish oil to prevent age-related cognitive decline in cognitively normal older adults