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Therefore, BH4 should not be understood solely as an enzyme cofactor, but should instead be depicted as a cytoprotective pathway that is finely regulated by the interaction of three different metabolic pathways, thus assuring specific intracellular concentrations

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Consistent with published structural data, AlphaFold2 predicted the association of a conserved surface-exposed hydrophobic cavity on VPS29 (defined by Leu152) with Pro-Leu (PL) motifs from TBC1D5 ( 141 PL 142 ) and VARP ( 713 PL 714 ) and for TBC1D5, the association of an additional 283 Ile-Pro-Phe 285 hydrophobic motif with VPS35 (Supplementary Fig

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13 Cryotherapy, the application of cold temperatures, is also a potential nonpharmacologic prevention tool for CIPN

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Article PubMed Google Scholar Shimada, K

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Defending someone, Especially when we don't know one another makes [my] heart happy

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