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Description

The B12 component is highly stable, but tirzepatide itself slowly degrades in solution

[DOI] [PubMed] [Google Scholar] 108.Crona DJ, Faso A, Nishijima TF, McGraw KA, Galsky MD, Milowsky MI

10.1038/s41401-024-01250-7 92 ZhangL.ShayJ

Conclusion: A solid oral dosage form coated with a combination of Eudragit NM30D/Eudragit L30 D-55 and a Eudragit L100 top coating improved the oral bioavailability of a GLP-1 agonist 14-fold in comparison with an enteric capsule coated with Eudragit L100