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The assumption of a uniform diffusion coefficient for M2 macrophages oversimplifies biological tissues, which often exhibit variable diffusion properties due to differences in extracellular matrix composition and tissue stiffness 25,27

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[144] demonstrated that sodium-citrate CQDs could prevent hen egg-white lysosome (HEWL) from forming mature amyloid fibrils, a common model of amyloidogenic protein aggregation [144]