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91 Aging also decreases the AID enzyme (activation-induced cytidine deaminase), which is responsible for class-switch recombination and the production of high-affinity antibodies

Methods: This analysis includes data from participants who have received at least 24 weeks ( 6 doses) of tobevibart 300 mg and elebsiran 200 mg subcutaneously every 4 weeks (Q4W) and are on nucleoside reverse transcriptase inhibitors in the ongoing MARCH, STRIVE, and THRIVE studies in participants with CHB (NCT04856085 and NCT05612581) and the SOLSTICE study in participants with CHD (NCT05461170)

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GST = glutathione S-transferase

Main outcome measures : Participation in the complete audit cycle, comparison of actual use of vitamin B-12 injections with agreed criteria of use , and assessment of improvement in use