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The lipoate moiety docked within the catalytic pocket, proximal to the catalytic serine-141 and histidine-296 residues (Fig

A C20 fatty-diacid moiety enables reversible serum-albumin binding and a markedly extended half-life relative to native incretins, and the balanced dual-receptor activity is what distinguishes it from single GLP-1 agonists like GLP-1 (Sema) and from the triple agonist GLP-3 (Reta)