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pH- or time-dependent nano-drug delivery systems have some limitations, such as the pH-dependent nanoparticles may not completely target the colon since the colon has a pH of 6.8, which is a similar pH present in the small intestines of ph 7.4, and the time is not fully certain for a gastrointestinal transit of the nanomaterials, which compels the time-dependent nanoparticles to sometimes neglect the targets (72)

Moreover, MenSCs from patients presented higher expression levels of the surface markers CD9, CD10, and CD29 than those from healthy individuals did, along with increased proliferative and invasive capacities (Nikoo et al., 2014)

Identification and functional analysis of endothelial tip cell-enriched genes

The role of autophagy in bone metabolism and clinical significance

Additionally, although primarily exhaled, acetone may be metabolized into usable energy sources such as pyruvate, lactate and acetate