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Furthermore, Ca 2+ -dependent C2 membrane binding disrupts C2/HECT interactions, but not Ca 2+ alone, whereas 14-3-3 protein binds to a flexible region of Nedd4-2 containing the WW2 and WW3 domains, thereby inhibiting its catalytic activity and membrane binding

Up-regulation of matrix metalloproteinase-3 in the dorsal root ganglion of rats with paclitaxel-induced neuropathy

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In future research, more detailed inclusion criteria should be formulated for clinical trials to reduce the incidence of adverse reactions