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Figure 5 Functional enrichment analysis of DEG identified in the contrasts above mentioned revealed 90 metabolic and signaling pathways differentially regulated in the groups MOD or SEV at endpoint A directly or indirectly related to the inflammatory response in blood, although patients had received glucocorticoid treatment for approximately 11 days prior to collection of samples to the study ( Figure 6A and Figure S4 )

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Abbreviations ATP: Adenosine triphosphate AD: Alzheimers disease ALS: Amyotrophic lateral sclerosis A: Amyloid- AMPK: AMP-activated protein kinase AP-1: Activator protein 1 ARE: Antioxidant response element enhancer sequence BDNF: Brain-derived neurotrophic CNS: Central nervous system CREB: CAMP response element-binding protein DA: Dopamine EAE: Experimental autoimmune encephalomyelitis mouse model FAD: Flavin adenine dinucleotide GST: Glutathione S-transferase GBM: Glioblastoma GSTP1: Glutathione-S-transferase Pi 1 HIF-1: Hypoxia-inducible factor 1-alpha HO-1: Heme oxygenase-1 IDH1: Isocitrate dehydrogenase 1 KEAP1: Kelch-like ECH-associated protein1 MCAO: Middle cerebral artery occlusion MS: Multiple sclerosis NQO1: NAD(P)H Quinone Dehydrogenase 1 Nrf2: Nuclear factor erythroid 2-related factor 2 NRP/B: Nuclear-restricted protein PD: Parkinson's disease PI3K: Phosphoinositide 3-kinase RIPK1: Receptor-interacting serine/threonine-protein kinase 1 ROS: Oxidative stresses SAH: Subarachnoid hemorrhage SN: Substantia nigra SOD1: Superoxide dismutase 1 TBI: Traumatic brain injury TDP-43: Transactive response DNA-binding protein 43 References Siegel D, Ross D