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Second, translational development should focus on dual-functional nanocarriers designed for striatal targeting and bloodbrain barrier penetrationusing DARPP-32-binding peptides to target affected MSNs and PEGylation to enhance brain entryloaded with mitochondria-directed ferroptosis modulators that both activate GPX4 and chelate iron, combined with mHTT-responsive release systems to avoid interference with normal neuronal function

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Palmieri et al., 2010)

Generally, these amino acid sequences have one or more of the following general structures: TTIDKX LXaHE and or FFWX S WVXLX S ML where X is selected from leucine or isoleucine, X 2 is selected from glutamine and asparagine, X 3 is selected from the methionine, lysine and aspartic acid, is selected from histidine, threanine and tyrosine and X 5 is selected from aspartic acid, glutamic acid and histidine