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Sphingolipids in metabolic disease: the good, the bad, and the unknown

FoxO1 and FoxO3 bind to the promoter regions of MUSA1 and SMART, and the FoxO3 deletion completely blunted the induction of SMART, but not other ubiquitin ligases

Furthermore, specific bacterial and prebiotic interventions are generally well tolerated, easily standardized and repeatable, and present a lower practical and ethical barrier compared to FMT