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For instance, an elevated ROS production by the respiratory chain is observed in obesity as a response to metabolic overload caused by excess macronutrients and increased substrate availability (44)

O-sulfated HA fragments represent another documented inhibitor class exhibiting dose-dependent, mixed-type inhibition with potent activity profiles [219]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Wilhelm S, Tavares AJ, Dai Q, Ohta S, Audet J, Dvorak HF, Chan WC