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Unlike the necrotic core, which undergoes irreversible energy failure, penumbral neurons experience sustained metabolic stress, delayed apoptosis, mitochondrial dysfunction, oxidative accumulation, and emerging ferroptosis signaling

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doi: 10.1016/s0006-291x(03)01504-3

To exclude the possibility that the increase in GSH level could reflect a generic response to D-HIS, a control strain (designated pCYC1-GAP1 in the following context) was constructed with GAP1 under the control of the constitutive promoter pCYC1

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