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The difficulty of controlling the phenomenon of crystal nucleation can lead to low reproducibility of industrial production, i.e

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10.1016/j.vph.2014.12.004 154 KimJ.-Y.LeeW.-R.KimK.-H.AnH.-J.ChangY.-C.HanS.-M.et al (2015b)

The decline isn't random

EPO is produced primarily in the kidneys in response to hypoxia and acts on erythroid progenitors by binding to the EPO receptor, promoting survival, proliferation, and differentiation [12]