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Rapid proliferation, high protein synthesis rates, hypoxia, nutrient deprivation, acidosis, and oxidative stress collectively impose a severe folding burden on the ER

However, the potential protective effects of N-acetylcysteine specifically in the context of social isolation-induced liver dysfunction remain largely unknown 15

Cryopreserved samples from 3 additional healthy controls and 3 additional patients that could not be analyzed fresh were also included in the study after confirming that ROS and glutathione levels in cryopreserved samples fell within the value range of fresh control and patient samples

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

In contrast, excessive or sustained activation of TLRs can promote chronic inflammation and has been implicated in the pathogenesis of numerous immune-mediated disorders (262)