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Phase IV - after the medicine has received regulatory approval, designed to evaluate the long-term effects

Fundamentally, this integrated design fits well with the R2C2 principles, aligned directly with SDG 6 (Clean Water and Sanitation) and SDG 7 (Affordable and Clean Energy), while also reducing waste and carbon in accordance with SDG 12 (Responsible Consumption and Production) and SDG 13 (Climate Action)

Methylation is a fundamental biochemical mechanism that plays a critical role in modulating gene expression during neuroinflammation and neurodegenerative disorders 43,44,45

Two other UIM-containing endocytic proteins, Hrs and Hbp, also interact with ubiquilin in a UIM-dependent manner, whereas epsin does not

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