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Mechanistically, Iso reduced ROS and MDA levels, enhanced SOD and CAT activity, and suppressed the NOX4/ROS/NF-B pathway by promoting Nrf2 nuclear translocation (Dai et al., 2018)

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These findings stress the importance of targeting mBzR/IMAC as a harbinger of more severe and permanent mitochondrial damage, which, through the ROS-induced ROS release mechanism, primes the opening of the PTP

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Thus, without the proteolytic activation of certain bacterial exotoxins, diseases such as dysentery or diphtheria would not occur