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doi:10.1111/ijcp.14455 Rist PM, Buring JE, Cook NR, Manson JE, Kurth T

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The existence of this correlation is supported by preclinical studies in mouse xenograft models, which showed that the therapeutic inhibition of angiogenesis reduces tumor vascularization and causes hypoxia, and therefore may promote c-Met-mediated invasion of malignant cells [50]