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However, scientific evidence currently points to the possibility that e-cigarettes are at least somewhat safer than conventional (combustible) cigarettes

Nicotine and Tobacco Research 6(Suppl 3):S363-S369

On the other hand, increased levels of SOD were observed in smokers, which could be the consequence of oxidative stress leading to a counter-regulatory upregulation of SOD [74]

While its not the primary cause of diseases associated with smoking (such as lung cancer, emphysema, or cardiovascular disease), nicotine does have various health effects on its own: Nicotine is highly addictive