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Gen Pharmacol 27:565573 Thornalley PJ (2003) Glyoxalase I-structure, function and a critical role in the enzymatic defence against glycation

When the body is exposed to stress, the paraventricular nucleus (PVN) of the hypothalamus secretes corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP), which stimulate the anterior pituitary to release adrenocorticotropic hormone (ACTH) (Figure 3)

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Moreover, in the plant Arabidopsis , the paraquat resistant 2 gene was recently shown to be a GSNO reductase and is a critical regulator of cell death [81]